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  6. Progesterone, 98%, Thermo Scientific Chemicals

Progesterone, 98%, Thermo Scientific Chemicals

Catalog Number AC225650050
Click to view available options
Quantity:
5 g
25 g
100 g
Packaging:
Glass bottle
57-83-0
C21H30O2
314.46
MFCD00003658
RJKFOVLPORLFTN-LEKSSAKUSA-N
progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
5994
CHEBI:17026
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
57-83-0
C21H30O2
314.46
MFCD00003658
RJKFOVLPORLFTN-LEKSSAKUSA-N
progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
5994
CHEBI:17026
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Description

Progesterone, CAS # 57-83-0, is a naturally occurring hormone required for maintenance of the uterine endothelium and suppression of estrogens.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation

• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility

Applications

• Progesterone signaling is relevant to the study of breast cancer

Literature References

Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.

Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.

TRUSTED_SUSTAINABILITY
Melting Point 126°C to 131°C
Color Brown-Yellow to Yellow
Loss on Drying 0.5% max. (500 mg, 105°C, 2 hrs)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Packaging Glass bottle
Quantity 5 g
Merck Index 15, 7889
Specific Rotation Condition +190° (20°C c=1,ethanol)
Specific Rotation + 190
Solubility Information Solubility in water: insoluble. Other solubilities: soluble in alcohol,acetone,dioxane,conc. h2so4
Formula Weight 314.46
Percent Purity 98%
Physical Form Crystalline Powder, Crystals or Chunks
Chemical Name or Material Progesterone
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Safety and Handling

Hazard Category GHS Signal Word: Warning
Hazard Statement GHS H Statement:
Suspected of causing cancer.
Precautionary Statement GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
EINECSNumber 200-350-6
SDS

RUO – Research Use Only

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