Thermo Scientific Chemicals Mitoxantrone Dihydrochloride

Description

 

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 70476-82-3
• Molecular Formula: C22H28N4O6.2HCl, C22H30Cl2N4O6
• Molecular Weight (g/mol): 517.40
• InChI Key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
• Synonym: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride;
• IUPAC Name: dihydrogen 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dichloride
• SMILES: [H+].[H+].[Cl-].[Cl-].OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(O)C=CC(O)=C1C2=O

• Quantity: 50 mg
• Description: Blue to black
• Content And Storage: -30°C to -10°C
• Formula Weight: 517.40
• Solubility: Soluble to 5 mM in water and to 75 mM in DMSO
• Product Type: Mitoxantrone dihydrochloride
• Form: Crystalline solid

Safety and Handling

EINECSNumber	274-619-1
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only