IKBKB Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of IKBKB.

Supplier:  Abnova Corporation PAB26814

Catalog No. 89-128-457

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM

Sequence: Q-K-Yp-T-V

Specifications

• Antigen: IKBKB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Immunofluorescence (1:100-1:200) The optimal working dilution should be determined by the end user.
• Gene: IKBKB
• Gene Symbols: IKBKB
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y199 of human IKBKB.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: Immunofluorescence
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic peptide of IKBKB.
• Formulation: In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Alias: FLJ40509/IKK-beta/IKK2/IKKB/MGC131801/NFKBIKB
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3551
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only