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CDKN1A Rabbit anti-Human, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of CDKN1A.
Supplier: Abnova Corporation PAB26715
Description
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq
Sequence: R-Q-Tp-S-MSpecifications
CDKN1A | |
Polyclonal | |
Unconjugated | |
Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user. | |
CDKN1A | |
CAP20/CDKN1/CIP1/MDA-6/P21/SDI1/WAF1/p21CIP1 | |
Rabbit | |
Affinity chromatography | |
RUO | |
1026 | |
Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
Western Blot | |
1 mg/mL | |
Rabbit polyclonal antibody raised against synthetic peptide of CDKN1A. | |
In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) | |
P38936 | |
CDKN1A | |
A synthetic peptide corresponding to residues surrounding T145 of human CDKN1A. | |
100 μg | |
Primary | |
Human | |
Liquid |
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