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Tocris Bioscience™ LSN 2463359
Potent and selective positive allosteric modulator at mGlu5
$207.64 - $844.48
Specifications
Purity | >99% |
---|---|
Product Type | LSN 2463359 |
Molecular Weight (g/mol) | 265.31 |
Inhibitors | LSN 2463359 |
Description
Potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908 -induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.Specifications
>99% | |
LSN 2463359 | |
265.31 | |
LSN 2463359 |
For Research Use Only
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