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  7. L-168,049, Tocris Bioscience™

L-168,049, Tocris Bioscience™

Catalog Number 231150
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
191034-25-0
C24H20BrClN2O
467.791
HHBOWXZOLYQFNY-UHFFFAOYSA-N
glucagon receptor antagonist ii, 4-3-5-bromo-2-propoxyphenyl-5-4-chlorophenyl-1h-pyrrol-2-yl pyridine, 2-4-pyridyl-5-4-chlorophenyl-3-5-bromo-2-propyloxyphenyl pyrrole, d0m3ar, glucagon antagonists diabetes, glucagon antagonists diabetes , merck & co, 4-3-5-bromo-2-propoxy-phenyl-5-4-chloro-phenyl-1h-pyrrol-2-yl-pyridine
5311276
4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
CCCOC1=C(C=C(C=C1)Br)C2=C(NC(=C2)C3=CC=C(C=C3)Cl)C4=CC=NC=C4
This item is not returnable. View return policy
191034-25-0
C24H20BrClN2O
467.791
HHBOWXZOLYQFNY-UHFFFAOYSA-N
glucagon receptor antagonist ii, 4-3-5-bromo-2-propoxyphenyl-5-4-chlorophenyl-1h-pyrrol-2-yl pyridine, 2-4-pyridyl-5-4-chlorophenyl-3-5-bromo-2-propyloxyphenyl pyrrole, d0m3ar, glucagon antagonists diabetes, glucagon antagonists diabetes , merck & co, 4-3-5-bromo-2-propoxy-phenyl-5-4-chloro-phenyl-1h-pyrrol-2-yl-pyridine
5311276
4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
CCCOC1=C(C=C(C=C1)Br)C2=C(NC(=C2)C3=CC=C(C=C3)Cl)C4=CC=NC=C4

Description

Potent, orally active human glucagon receptor antagonist

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo.
Quantity 50 mg
Formula Weight 467.79
Percent Purity >99%
Chemical Name or Material L-168, 049

Safety and Handling

Recommended Storage Store at Room Temperature
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